Angiopoietin-Like 3
نویسندگان
چکیده
منابع مشابه
Pentraxin-3, Angiopoietin-Like Protein-3, Angiopoietin-Like Protein-4 and Angiopoietin-Like Protein-8 Levels in Morbid Obese Children
A low-grade inflammatory state accompanies obesity and metabolic syndrome (MetS), which are risk factors for cardiovascular diseases (CVD) in children’s future lives. The aim of this study is to investigate possible associations of pentraxin 3 (PTX3), a promising new marker for CVDs, with angiopoietin-like proteins (ANGPTL) in morbid obese (MO) children and their potential uses in the prediagno...
متن کاملRegulation of the angiopoietin-like protein 3 gene by LXR.
Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angptl3), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid metabolism. In this study, we show that the Angptl3 gene is a direct target of the liver X receptor (LXR). Mice fed a high cholesterol diet exhibited a...
متن کاملAngiopoietin-like 4 (Angptl4)
Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability to inhibit lipoprotein lipase, Angptl4 stimulates intracellular adipocyte lip...
متن کاملAngiopoietin-Like Proteins
besity and related metabolic diseases (known as the metabolic syndrome (MetS)) are associated with increased risk of cardiovascular disease (CVD). Thus, it is necessary to both understand the underlying molecular basis and develop effective preventive and therapeutic approaches. We and others have independently identified 7 angiopoietin-like proteins (Angptls), namely, Angptl1/angiopoietin-rela...
متن کاملBiological characterization of angiopoietin-3 and angiopoietin-4.
The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs. In experiments with human endothelial cell lines, Ang3 was identified as an antagonist of Tie2 and Ang4 was identified as an agonist of Tie2. However, the biological roles of Ang3 and An...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2019
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2019.05.008